Chronobiology — Time Inside Every Cell

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Body Clock Events

The Molecular Loop

The core clock is a transcription-translation feedback loop: CLOCK and BMAL1 proteins activate PER and CRY genes. PER/CRY proteins accumulate and then inhibit CLOCK/BMAL1. The cycle takes ~24 hours and runs in virtually every nucleated cell in your body — independently of the brain.

Timezone Misalignment

The body clock lags behind external time by up to 1 hour per day of travel:

The Reframe

You are not one clock — you are a coordinated orchestra of ~37 trillion clocks. Your liver has its own circadian rhythm, independent of your brain. The master clock in your suprachiasmatic nucleus only synchronizes them. Mess with the conductor and the orchestra slowly drifts.